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[Diagnostic value of the captopril test in patients with arterial hypertension]
Insights
The captopril test shows limited diagnostic value for renin-dependent hypertension. It was positive in most patients but only correlated with renin activity in renovascular hypertension and arteritis cases.
Area of Science:
- Nephrology
- Cardiology
- Hypertension Research
Background:
- Renin-dependent hypertension is a critical condition requiring accurate diagnostics.
- The captopril test is a commonly used diagnostic tool for identifying renin-dependent hypertension.
Purpose of the Study:
- To evaluate the diagnostic efficacy of the captopril test in various forms of hypertension.
- To assess the correlation between captopril test results, plasma renin activity, and blood pressure changes.
Main Methods:
- The captopril test was administered to 214 hypertensive patients (30 renovascular hypertension, 50 arteritis, 71 with parenchymal nephropathy, 63 primary hypertension) under standardized conditions (night rest, high sodium diet).
- Positive test results and changes in plasma renin activity and blood pressure were recorded and analyzed.
Main Results:
- Positive captopril test results were observed in 76.67% of renovascular hypertension, 70.59% of arteritis, 53.52% of hypertension with parenchymal nephropathy, and 63.49% of primary hypertension patients.
- A significant correlation between increased plasma renin activity and decreased blood pressure post-captopril was found exclusively in patients with renovascular hypertension and arteritis.
Conclusions:
- The captopril test demonstrates a high rate of positive results across different hypertensive groups.
- Its diagnostic utility for renin-dependent hypertension is questionable, as significant correlations were limited to specific patient subgroups.
Abstract:
In 30 patients with renovascular hypertension, 50 with hypertension in a course of arteries, 71 hypertensive subjects with coexisting parenchymal nephropathy and in 63 with primary hypertension the captopril test was performed after 8 hours night rest and within high sodium diet. Positive test result was stated in 76.67% of patients with renovascular hypertension, in 70.59% of patients with arteritis, in 53.52% of patients with hypertension and coexisting parenchymal nephropathy and in 63.49% of patients with primary hypertension. Significant correlation between increase of plasma renin activity and blood pressure decrease after captopril administration was only stated in patients with renovascular hypertension and in those with arteritis. Results of performed studies impaired the captopril test value in diagnostics of renin-dependent hypertension.