Related Experiment Video
Updated: Jan 24, 2026
08:05
Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice
Published on: March 1, 2017
9.7K
Research Advances in Biomarkers for Demyelinating Optic Neuritis
Xiang Chen1, Shi-hui Wei1, Mao-nian Zhang1
1Department of Ophthalmology,Chinese PLA General Hospital,Beijing 100853,China.
Summary
Optic neuritis is inflammation of the optic nerve. This review covers biomarkers that aid in diagnosing and treating demyelinating optic neuritis, the most common form.
Area of Science:
- Ophthalmology
- Neuroimmunology
- Biomarker Discovery
Background:
- Optic neuritis involves inflammation of the optic nerve.
- Demyelinating optic neuritis is the most frequent subtype.
- Biomarkers are crucial for understanding disease mechanisms and guiding treatment.
Purpose of the Study:
- To review current knowledge on biomarkers for demyelinating optic neuritis.
- To highlight the diagnostic and prognostic potential of identified biomarkers.
- To provide an overview for researchers and clinicians in the field.
Main Methods:
- Literature search for studies on optic neuritis biomarkers.
- Review and synthesis of data on established and emerging biomarkers.
- Categorization of biomarkers based on their pathophysiological relevance.
Main Results:
- Various biomarkers reflect the inflammatory and demyelinating processes in optic neuritis.
- Specific biomarkers show potential for early diagnosis and monitoring disease activity.
- The article consolidates information on a range of relevant biomarkers.
Conclusions:
- Biomarkers are essential tools for managing demyelinating optic neuritis.
- Further research is needed to validate and implement novel biomarkers in clinical practice.
- Understanding biomarkers can lead to more personalized treatment strategies.
More Related Videos
Related Concept Videos
01:30Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques
505
Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
505
00:56Extraction: Advanced Methods
1.1K
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.1K
02:22Overview of Advanced Functional Groups
29.4K
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.4K
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
825
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
825
01:08Sample Preparation for Analysis: Advanced Techniques
1.3K
Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
1.3K
02:24Properties of Enantiomers and Optical Activity
21.5K
It is essential to understand the difference between chiral and achiral interactions and the implications thereof in optical activity and their applications. Just as our feet, which are chiral, interact uniquely with chiral objects, such as a pair of shoes, but identically with achiral socks, enantiomers of a molecule exhibit different properties only when they interact with other chiral media. An example of a significant implication from this facet is the phenomenon known as optical activity,...
21.5K