Stress Hyperglycemia During Surgery and Anesthesia: Pathogenesis and Clinical Implications
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Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Nadine E Palermo1, Roma Y Gianchandani2, Marie E McDonnell3
1Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Ave, Suite 381, Boston, MA, 02115, USA. npalermo@bwh.harvard.edu.
Abstract:
Numerous studies have demonstrated an association between hyperglycemia in the perioperative period and adverse clinical outcomes. Many patients who experience hyperglycemia while hospitalized do not have a known history of diabetes and experience a transient phenomenon often described as "stress hyperglycemia" (SH). We discuss the epidemiology and pathogenesis of SH as well as evidence to date regarding predisposing factors and outcomes. Further research is needed to identify the long-term sequelae of SH as well as perioperative measures that may modulate glucose elevations and optimal treatment strategies.
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