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Updated: Mar 24, 2026
A Novel Rescue Technique for Difficult Intubation and Difficult Ventilation
Published on: January 17, 2011
Closed-loop ventilation mode (IntelliVent®-ASV) in intensive care unit: a randomized trial
Emilie Bialais1, Xavier Wittebole, Laurence Vignaux
1Department of Intensive Care, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium - emilie.bialais@uclouvain.be.
IntelliVent-ASV, an automated ventilation mode, reduced healthcare team workload and maintained safe, effective mechanical ventilation for ICU patients compared to conventional methods.
Area of Science:
- Critical Care Medicine
- Respiratory Therapy
- Medical Engineering
Background:
- Closed-loop ventilation systems offer automated, individualized adjustments.
- IntelliVent-ASV represents a novel closed-loop ventilation mode.
Purpose of the Study:
- To compare IntelliVent-ASV with conventional ventilation modes.
- Evaluate safety, efficacy, and healthcare team workload over 48 hours.
Main Methods:
- Randomized controlled trial involving 80 ICU patients requiring mechanical ventilation >48 hours.
- Breath-by-breath recording of ventilation parameters.
- Assessment of manual adjustments for workload; time in optimal/non-optimal ranges for safety/efficacy.
Main Results:
- IntelliVent-ASV showed similar safety and efficacy for most parameters, except for more optimal SpO2 and VT.
- Lower PEEP and higher PETCO2 were observed with IntelliVent-ASV.
- IntelliVent-ASV significantly reduced manual adjustments but increased parameter variability (PEEP, PINSP).
Conclusions:
- IntelliVent-ASV requires less manual intervention.
- Automated ventilation provides safe and effective support for tidal volume, respiratory rate, SpO2, and PETCO2.
- Increased variability in PEEP and inspiratory pressure is noted with IntelliVent-ASV.
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