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Updated: Mar 24, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Sequential programmable self-assembly: Role of cooperative interactions.

Jonathan D Halverson¹, Alexei V Tkachenko¹

¹Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York 11973, USA.

The Journal of Chemical Physics

|March 10, 2016

Summary

This summary is machine-generated.

We introduce sequential programmable self-assembly for designing complex nanoscale structures. Utilizing DNA spiders with cooperative binding significantly reduces errors, enabling precise bottom-up construction of arbitrary architectures.

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Area of Science:

Nanotechnology
Materials Science
Biophysics

Background:

Bottom-up fabrication of nanoscale architectures is crucial for advanced materials and devices.
Traditional self-assembly methods often face limitations in precision and error rates.
Biochemical processes utilize cooperativity for high-fidelity signaling and regulation.

Purpose of the Study:

To develop a general strategy for programmable self-assembly of arbitrary multi-particle architectures.
To overcome limitations of pairwise additive interactions in self-assembly.
To implement a high-precision self-assembly strategy using cooperative interparticle binding.

Main Methods:

Proposed a sequential programmable self-assembly strategy.
Introduced cooperative interparticle binding to enhance assembly precision.
Designed and utilized DNA spiders as smart interparticle linkers with built-in cooperativity.
Simulated the assembly of various mesostructures, including tetrahelix derivatives.

Main Results:

Naive pairwise interactions lead to high error rates in self-assembly.
Cooperative binding, implemented via DNA spiders, significantly reduces assembly errors.
Demonstrated the versatility of the method by assembling complex finite and repeating mesostructures.
Achieved essentially error-free sequential self-assembly with sufficient binding cooperativity.

Conclusions:

Sequential programmable self-assembly with cooperative binding offers a robust strategy for nanoscale construction.
DNA spiders provide an effective platform for implementing cooperative binding in self-assembly.
The developed approach enables the precise bottom-up design and fabrication of diverse nanoparticle architectures.