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[Hyperkeratosis lenticularis perstans (Flegel)]
I Sánchez Jacob1, A Miranda, N Pérez Oliva
1Hospital Universitario de Valladolid.
Medicina Cutanea Ibero-Latino-Americana
|January 1, 1989
Summary
This case report details hyperkeratosis lenticularis perstans, a rare skin condition. Treatment with etretinate and topical 5-fluorouracil showed satisfactory results for the patient.
Area of Science:
- Dermatology
- Histopathology
- Electron Microscopy
Background:
- Hyperkeratosis lenticularis perstans (also known as Flegel disease) is a rare, chronic disorder of keratinization.
- It typically presents as small, hyperkeratotic papules on the lower extremities.
Observation:
- A case of a 67-year-old female patient with characteristic hyperkeratotic papules on her lower extremities is presented.
- Clinical, histological, and ultrastructural findings were documented.
Findings:
- Ultrastructural examination revealed the absence of Odland bodies.
- Persistence of desmosomes in the stratum corneum was noted.
- Lymphocytes with cerebriform nuclei were observed within the inflammatory infiltrate.
Implications:
- This report contributes to the understanding of the ultrastructural pathology of hyperkeratosis lenticularis perstans.
- Successful treatment outcomes with etretinate and topical 5-fluorouracil are highlighted.
- Further research into the pathogenesis and treatment of this condition is warranted.