Sinopulmonary Complications in Subjects With Primary Immunodeficiency
Abdullah Owayed1, Waleed Al-Herz2
1Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait. Pulmonary Unit, Department of Pediatrics, Mubarak Hospital, Kuwait City, Kuwait.
Respiratory Care
|March 10, 2016
Summary
Sinopulmonary complications are frequent and serious in primary immunodeficiency disorders, impacting patients even after diagnosis and treatment. Pulmonologists are crucial for managing these severe respiratory issues in affected individuals.
Area of Science:
- Immunology
- Pulmonology
- Clinical Medicine
Background:
- Primary immunodeficiency disorders (PIDs) are a group of genetic conditions affecting the immune system.
- Sinopulmonary complications are a major cause of morbidity and mortality in patients with PIDs.
Purpose of the Study:
- To determine the frequency and spectrum of sinopulmonary complications in patients with primary immunodeficiency disorders.
- To analyze the impact of these complications on patient outcomes.
Main Methods:
- Prospective registration of patients with primary immunodeficiency in the Kuwait National Primary Immunodeficiency Disorders Registry from January 2004 to December 2013.
- Analysis of sinopulmonary manifestations, their timing, and associated mortality.
Main Results:
- 202 patients were registered, with combined immunodeficiencies being the most prevalent type (32.1%).
- Sinopulmonary manifestations occurred in 63% of subjects, with pneumonia (80 subjects) and otitis media (59 subjects) being most common.
- Pulmonary complications contributed to 42% of the 57 deaths (28% overall mortality).
Conclusions:
- Sinopulmonary complications are a significant and persistent problem in primary immunodeficiency disorders.
- These complications can occur both at presentation and after diagnosis, highlighting the need for ongoing surveillance.
- Pulmonologists play a vital role in the comprehensive management of patients with primary immunodeficiency disorders.
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