Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

One-Compartment Open Model for IV Bolus Administration: General Considerations01:19

One-Compartment Open Model for IV Bolus Administration: General Considerations

919
The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...
919
Two-Compartment Open Model: IV Infusion01:15

Two-Compartment Open Model: IV Infusion

718
A two-compartment model is a vital tool in pharmacokinetics, providing an essential understanding of drug behavior, especially for those administered via zero-order intravenous infusion. This model outlines two compartments: the central compartment, where elimination occurs, and the peripheral compartment.
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...
718
One-Compartment Model: IV Infusion01:09

One-Compartment Model: IV Infusion

665
Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
665
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

334
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
334
One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance00:56

One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance

472
Clearance is a key pharmacokinetic parameter that quantifies the volume of body fluid from which a drug is entirely removed within a specific time frame. It is crucial in assessing how a drug is eliminated from the body and has critical clinical applications.
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
472
Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

378
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
378

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Safety Action Feedback and Engagement (SAFE) Loop: Initial Testing and Refinement of a Novel Intervention to Enhance Hospital Incident Reporting and Patient Safety.

Journal of patient safety·2026
Same author

The Safety Action Feedback and Engagement (SAFE) Loop: Initial Testing and Refinement of a Novel Intervention to Enhance Hospital Incident Reporting and Patient Safety.

medRxiv : the preprint server for health sciences·2025
Same author

Comparing the Safety Action Feedback and Engagement (SAFE) Loop with an established incident reporting system: Study protocol for a pragmatic cluster randomized controlled trial.

Contemporary clinical trials communications·2023
Same author

Hardwiring Safety Into the Computer System: One Hospital's Actions to Provide Technology Support for U-500 Insulin.

P & T : a peer-reviewed journal for formulary management·2019
Same author

Chloral Hydrate: Is It Still Being Used? Are There Safer Alternatives?

P & T : a peer-reviewed journal for formulary management·2019
Same author

Accidental IV Infusion of Heparinized Irrigation in the Operating Room.

P & T : a peer-reviewed journal for formulary management·2019

Related Experiment Video

Updated: Mar 24, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
09:57

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

14.0K

Understanding and Managing Intravenous Container Overfill.

Matthew Grissinger

    P & T : a Peer-Reviewed Journal for Formulary Management
    |March 10, 2016
    PubMed
    Summary

    Understanding intravenous (IV) container overfill is crucial for patient safety. This knowledge helps prevent medication errors and ensures accurate drug administration.

    Area of Science:

    • Pharmaceutical Science
    • Medical Device Engineering
    • Patient Safety Research

    Background:

    • Intravenous (IV) fluid administration is a cornerstone of modern medical care.
    • Inaccurate medication dosing due to IV container overfill poses a significant risk to patient outcomes.
    • Standardized protocols for IV container filling and verification are essential.

    Purpose of the Study:

    • To investigate the prevalence and impact of IV container overfill.
    • To identify factors contributing to overfill in IV fluid preparation.
    • To propose strategies for mitigating overfill and enhancing medication safety.

    Main Methods:

    • Analysis of IV container fill volumes using gravimetric and volumetric methods.
    • Review of manufacturing processes and quality control measures for IV containers.

    More Related Videos

    DUCT: Double Resin Casting followed by Micro-Computed Tomography for 3D Liver Analysis
    12:39

    DUCT: Double Resin Casting followed by Micro-Computed Tomography for 3D Liver Analysis

    Published on: September 28, 2021

    3.8K
    A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
    06:59

    A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

    Published on: November 9, 2016

    31.5K

    Related Experiment Videos

    Last Updated: Mar 24, 2026

    A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
    09:57

    A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

    Published on: July 13, 2019

    14.0K
    DUCT: Double Resin Casting followed by Micro-Computed Tomography for 3D Liver Analysis
    12:39

    DUCT: Double Resin Casting followed by Micro-Computed Tomography for 3D Liver Analysis

    Published on: September 28, 2021

    3.8K
    A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
    06:59

    A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

    Published on: November 9, 2016

    31.5K
  • Clinical data review to assess the incidence of overfill-related adverse events.

    • Main Results:

    • Quantification of typical overfill volumes in commonly used IV containers.
    • Identification of specific manufacturing steps or quality control lapses associated with overfill.
    • Correlation between IV container overfill and potential medication dosing errors.

    Conclusions:

    • IV container overfill is a quantifiable issue with direct implications for patient safety.
    • Implementing enhanced quality control during IV container manufacturing can reduce overfill.
    • Further research into standardized fill-volume verification is recommended to ensure accurate drug delivery.