Serum C-reactive protein in asthma and its ability in predicting asthma control, a case-control study

Area of Science:

• Pulmonary Medicine
• Clinical Immunology
• Biomarker Research

Background:

• Elevated serum high-sensitive C-reactive protein (hs-CRP) is linked to asthma severity.
• Previous studies suggest an association between hs-CRP levels and asthma.
• Understanding hs-CRP's role is crucial for asthma management.

Purpose of the Study:

• To compare serum hs-CRP levels in asthma patients versus healthy controls.
• To evaluate the predictive capability of serum hs-CRP for asthma control.
• To investigate the correlation between hs-CRP and asthma severity.

Main Methods:

• Serum hs-CRP measured via ELISA using a high-sensitivity kit.
• Asthma severity assessed using the Asthma Control Test.
• Statistical analyses included Spearman, chi-square, and ROC analysis with AUC for predictive accuracy.

Main Results:

• 120 asthma patients and 115 controls were studied.
• Asthma patients showed significantly higher median serum hs-CRP than controls (P=0.001).
• hs-CRP levels correlated with asthma control, decreasing in well-controlled asthma (P=0.024), and predicted control with AUCs of 0.635 and 0.625.

Conclusions:

• Serum hs-CRP is elevated in asthma and increases with disease severity.
• hs-CRP levels decrease with improved asthma control.
• Serum hs-CRP measurement is a valuable tool for predicting asthma control and treatment response.