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Updated: Mar 24, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Esophageal Eosinophilia Treated With Long-Duration Proton Pump Inhibitor Therapy
Ernest L DiGiovanni1, Anne L Champeaux2, May R Arroyo2
1Largo Medical Center, NOVA Southeastern University College of Osteopathic Medicine, Largo, FL.
Abstract:
We present a case of proton pump inhibitor-responsive eosinophilic esophagitis (PPI-REE) in a patient with severe dysphagia and markedly elevated baseline esophageal eosinophilia that was previously deemed unresponsive to PPI. Upon reintroduction to PPI therapy with monthly endoscopy and dilation over the course of 4 months, the patient improved clinically and resolved her mucosal eosinophilia. Our case suggests that a longer duration of PPI therapy may be required for histologic improvement, especially in patients with very high mucosal eosinophil count.
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