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Data for the analysis of PolyHIPE scaffolds with tunable mechanical properties for bone tissue engineering
Robert Owen1, Colin Sherborne2, Gwendolen C Reilly1
1Department of Materials Science and Engineering, University of Sheffield, INSIGNEO Institute for in silico medicine, The Pam Liversidge Building, Sir Frederick Mappin Building, Mappin Street, Sheffield S1 3JD, United Kingdom.
Data in Brief
|March 10, 2016
Summary
This study provides mechanical and biological data for acrylate-based PolyHIPE scaffolds used in bone tissue engineering. The data includes mechanical properties, scaffold openness, and cell responses for various compositions.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Polymer Chemistry
Background:
- Bone tissue engineering requires scaffolds with tunable mechanical properties to mimic native bone.
- PolyHIPE (highly cross-linked polymer) scaffolds offer potential for bone regeneration.
- Understanding the relationship between scaffold composition and mechanical performance is crucial.
Purpose of the Study:
- To present comprehensive data on the mechanical characterization of acrylate-based PolyHIPE scaffolds.
- To provide data on the degree of openness (DOO) for different scaffold compositions.
- To report cell viability and alkaline phosphatase (ALP) activity on these scaffolds.
Main Methods:
- Fabrication of 20 acrylate-based PolyHIPE compositions using emulsion templating.
- Mechanical testing to determine Young's modulus, ultimate tensile stress, and strain at failure.
- Measurement of the degree of openness (DOO) and assessment of cell viability and ALP activity.
Main Results:
- Excel files containing detailed mechanical test results for each PolyHIPE specimen.
- Data illustrating the variability in mechanical properties and DOO across different compositions.
- Results of cell viability and ALP activity assays indicating scaffold biocompatibility.
Conclusions:
- The presented data supports the development of PolyHIPE scaffolds with tailored mechanical properties for bone tissue engineering applications.
- This dataset facilitates further research into structure-property relationships in emulsion-templated scaffolds.
- The findings contribute to the understanding of scaffold performance in a biological context.
