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Author Spotlight: Unveiling the Potential of Unpurified Recombinant AAVs in Cell Culture Research
Published on: October 20, 2023
Data on interaction between adeno-associated virus and U87 cell via cRGD chemical modification
Chuanling Zhang1, Tianzhuo Yao1, Yongxiang Zheng1
1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, No. 38, Xueyuan Road, Beijing 100191, China.
Abstract:
RGD tripeptide is a specific, high-affinity ligand for integrin, which is highly expressed in cancer cells. We previously reported that cRGD chemically modified AAV2 (AAV2(N587+1/azido+RGD)) showed significantly enhanced infectivity compared to RGD genetically inserted AAV2 (AAV2(N587+RGD)) (10.1016/j.biomaterials.2015.11.066) [1]. Herein we provide the binding ability analysis of RGD modified AAV2 and U87 cell by flow cytometry and the theoretical working model of RGD-αvβ3 integrin interaction.
