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Updated: Mar 24, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

Published on: September 13, 2018

Virus-Host Interactions: From Unbiased Genetic Screens to Function.

Holly Ramage¹, Sara Cherry¹

¹Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104; email: hramage@mail.med.upenn.edu , cherrys@mail.med.upenn.edu.

Annual Review of Virology

|March 10, 2016

Summary

Understanding virus-host interactions is key to developing antiviral therapies. Recent advances in screening technologies have revealed host factors viruses use and antiviral factors that fight infection.

Keywords:

RNA interference antiviral host factors gain-of-function screens haploid genetic screens high-throughput screening pro-viral host factors

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Last Updated: Mar 24, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors

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Published on: September 13, 2018

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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

Area of Science:

Virology
Immunology
Molecular Biology

Background:

Viral infections pose significant threats to human health, necessitating a deeper understanding of virus-host interactions.
Pathogenesis mechanisms and antiviral therapy development rely on deciphering complex virus-host cell relationships.
Recent technological advancements have enabled high-throughput screening of these interactions.

Purpose of the Study:

To review findings from recent virus-host interaction screens.
To discuss the implications of these findings for understanding viral pathogenesis.
To provide insights into future directions for screening strategies.

Main Methods:

High-throughput screening methodologies.
Advances in RNA interference (RNAi).
Proteomics and genetic tools (e.g., haploid cell lines).

Main Results:

Identification of host factors exploited by viruses to facilitate infection.
Discovery of antiviral factors that restrict viral replication.
A growing dataset detailing critical virus-host contact points.

Conclusions:

Virus-host interaction screens are crucial for identifying therapeutic targets.
Continued development of screening strategies will accelerate antiviral drug discovery.
Understanding these interactions is fundamental for combating viral diseases.