Clear-Cell Atypical Fibroxanthoma: A Combined Immunohistochemistry Analysis
Cristina N Brau Javier1, Diana C Valentín Colón, Jorge L Sánchez
1Department of Dermatology, University of Puerto Rico, San Juan, Puerto Rico.
The American Journal of Dermatopathology
|March 10, 2016
Summary
A rare clear-cell variant of atypical fibroxanthoma, a low-grade sarcoma, presented with rapid growth in a 63-year-old female. Diagnosis involved specific immunohistochemistry markers, highlighting key positive and negative indicators for this rare tumor.
Area of Science:
- Dermatopathology
- Oncology
- Surgical Pathology
Background:
- Atypical fibroxanthoma is a rare, low-grade soft tissue sarcoma.
- It typically presents as a skin nodule with atypical spindled cells.
Observation:
- A rare clear-cell variant of atypical fibroxanthoma exhibited rapid growth in a 63-year-old female patient.
- A keratoacanthoma developed at the site of prior Mohs surgery.
Findings:
- The study details the differential diagnosis for clear cell proliferation.
- Key immunohistochemistry markers (CD10, procollagen 1, CD68, CD163, CD99, S100A6) and negative markers (S100, cytokeratin, desmin) are reviewed for accurate diagnosis.
Implications:
- Accurate diagnosis of clear-cell atypical fibroxanthoma relies on careful interpretation of immunohistochemistry.
- Understanding these markers is crucial for distinguishing this rare variant from other clear cell lesions.
- The association with prior Mohs surgery warrants further investigation.
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