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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood Transfusion01:15

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Transmission-based Precautions II: Airborne and Protective Environment01:25

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Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
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Healthcare Associated Infections II: Preventive Measures01:22

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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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Standard Precaution01:26

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Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
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Rh Blood Group01:19

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The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
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Updated: Mar 24, 2026

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination
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Transfusion practices and infectious risks.

Aryeh Shander1, Gregg P Lobel1, Mazyar Javidroozi1

  • 1a Department of Anesthesiology and Critical Care Medicine , Englewood Hospital and Medical Center and TeamHealth Research Institute , Englewood , NJ , USA.

Expert Review of Hematology
|March 10, 2016
PubMed
Summary
This summary is machine-generated.

Transfusion-transmitted infections are a serious risk, but safety measures have lowered them. Emerging infections and transfusion risks like nosocomial infections require ongoing vigilance and judicious blood use.

Keywords:
Transfusionblood testinginfectionironoutcomespatient blood managementtransfusion complicationtransfusion strategytransfusion-related immunomodulationtransfusion-transmitted infection

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Area of Science:

  • Hematology
  • Infectious Diseases
  • Public Health

Background:

  • Transfusion-transmitted infections (TTIs) are a significant risk associated with allogeneic blood transfusions.
  • Current safety strategies have reduced TTI risks to historic lows in developed countries.

Purpose of the Study:

  • To review the current landscape of transfusion safety, focusing on TTIs and the broader impacts of allogeneic transfusion.
  • To discuss emerging threats and the need for enhanced pathogen inactivation and surveillance.

Main Methods:

  • Literature review of transfusion safety practices, TTI risks, and transfusion-associated immune modulation.
  • Analysis of factors contributing to increased patient risk following transfusion.

Main Results:

  • While TTIs are at historic lows due to donor screening, testing, and pathogen inactivation, emerging infections pose a future threat.
  • Allogeneic transfusion is linked to poorer patient outcomes, including increased nosocomial infections, potentially due to immunosuppression, iron overload, and contamination.

Conclusions:

  • Enhanced pathogen inactivation and horizon screening are crucial for mitigating future TTI risks.
  • Judicious, evidence-based use of allogeneic blood components is essential to ensure benefits outweigh transfusion risks, particularly concerning patient outcomes.