Related Experiment Video
Updated: Mar 24, 2026
11:02
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
21.9K
Dermatological side effects of intravesical Mitomycin C: Delayed hypersensitivity
A Colomer Gallardo1, R Martínez Rodríguez1, C Castillo Pacheco1
1Servicio de Urología. Hospital Universitari Germans Trias i Pujol. Universitat Autònoma de Barcelona. España.
Archivos Espanoles De Urologia
|March 10, 2016
Summary
Intravesical Mitomycin C for bladder cancer can cause skin side effects like palm and plantar dermatitis. Two types, contact and delayed hypersensitivity, were observed, with the latter requiring corticosteroid treatment.
Area of Science:
- Oncology
- Dermatology
- Urology
Background:
- Non-muscle invasive bladder cancer (NMIBC) is often treated with intravesical chemotherapy.
- Mitomycin C is a commonly used intravesical agent for NMIBC.
- Dermatologic side effects are potential complications of intravesical therapies.
Observation:
- This study reports two cases of palm and plantar dermatitis following intravesical Mitomycin C treatment.
- The observed dermatitis presented as a significant side effect in patients with NMIBC.
Findings:
- Two distinct types of dermatitis pathogenesis were identified: contact dermatitis and delayed hypersensitivity dermatitis.
- Non-allergic contact dermatitis is a frequently reported side effect.
- Dermatitis secondary to delayed hypersensitivity (Type IV) is less common and necessitates corticosteroid intervention.
Implications:
- Understanding these dermatologic side effects is crucial for managing patients undergoing intravesical Mitomycin C therapy.
- Prompt recognition and appropriate treatment, including corticosteroids for hypersensitivity reactions, can improve patient outcomes.
- Further research into the mechanisms and prevention of these side effects is warranted.
Related Concept Videos
01:29Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
162
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
162
01:01Hypersensitivity Reactions: Cytolytic Reactions
118
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
118
01:30Drug Toxicity: Allergic Reactions
129
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
129
01:30Hypersensitivities
8.2K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
8.2K
01:19Hypersensitivity Reactions: Immune-Complex Reactions
128
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
128