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Neurolymphomatosis in a cat.
Masashi Sakurai1, Kazushi Azuma, Arata Nagai
1Department of Veterinary Pathology, Yamaguchi University, Yamaguchi, Yamaguchi 753-8511, Japan.
The Journal of Veterinary Medical Science
|March 11, 2016
Summary
A cat developed progressive neurological issues like ataxia and seizures due to neoplastic lymphocytes infiltrating its nerves. This condition, resembling human neurolymphomatosis, highlights the importance of diagnosing feline neurological diseases.
Area of Science:
- Veterinary Neurology
- Comparative Pathology
- Oncology
Background:
- Lymphoma can affect the nervous system in various species.
- Neurolymphomatosis is a rare form of lymphoma involving peripheral nerves and the central nervous system.
- Understanding feline neurological presentations is crucial for diagnosis.
Observation:
- A 9-year-old cat presented with chronic progressive ataxia and seizures.
- Necropsy revealed swollen spinal roots, spinal ganglions, brachial plexus, and cranial nerves with white mass lesions.
- A mass was also identified in the right frontal lobe of the cerebrum.
Findings:
- Histopathology confirmed neoplastic lymphocytes extensively infiltrating peripheral nerves.
- These lymphocytes extended into the cerebral and spinal parenchyma along nerve tracts.
- Immunohistochemistry showed most neoplastic lymphocytes were positive for CD20, a B-cell marker.
Implications:
- This case presents a feline counterpart to human neurolymphomatosis.
- The findings emphasize the potential for lymphoma to mimic other neurological disorders in cats.
- Further research into feline neurolymphomatosis could improve diagnostic and therapeutic strategies.
