Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

66
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
66
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A luminescent metal-organic polyhedron for enzyme-free detection of uric acid.

Analytical methods : advancing methods and applications·2026
Same author

Heterogeneous "Battery-Bulb" Coupling: Energy Transfer Mechanism from ZnGa<sub>2</sub>O<sub>4</sub>:Mn<sup>2+</sup> → La<sub>2</sub>MgTiO<sub>6</sub>:Er<sup>3+</sup> and NIR-IIb Afterglow Imaging.

ACS applied bio materials·2026
Same author

Optimising thermal performance in data centre server racks via a parametric layout configuration study.

Scientific reports·2026
Same author

Safety, effectiveness and treatment patterns of sodium zirconium cyclosilicate for hyperkalemia management in China: actualize study.

Frontiers in pharmacology·2026
Same author

Improving cognitive performance through adaptive audiovisual perceptual training in community-dwelling older adults.

BMC geriatrics·2026
Same author

A Missing Source of Atmospheric NO<sub>2</sub><sup>-</sup>: Heterogeneous Dark Transformation of PAN on Industrial Mineral Dust.

Environmental science & technology·2026

Related Experiment Video

Updated: Mar 24, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

9.3K

Trace Elements and Chemotherapy Sensitivity.

Zhihui Liu1, Weiping Yang2, Gang Long3

  • 1The First Chemotherapy Department, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi Province, 530021, China.

Biological Trace Element Research
|March 11, 2016
PubMed
Summary
This summary is machine-generated.

Trace elements like selenium and manganese in hepatocellular carcinoma (HCC) tissues may affect chemotherapy response. Lower levels of these elements in cancer tissues correlated with reduced sensitivity to certain drugs, suggesting a potential role in treatment efficacy.

Keywords:
CarboplatinDoxorubicinDrug sensitivityLiver cancerManganeseSeleniumTrace elements

More Related Videos

Modeling Chemotherapy Resistant Leukemia In Vitro
08:41

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

9.7K
Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
08:32

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

1.4K

Related Experiment Videos

Last Updated: Mar 24, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

9.3K
Modeling Chemotherapy Resistant Leukemia In Vitro
08:41

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

9.7K
Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes
08:32

Genome-Wide CRISPR Screen for Unveiling Radiosensitive and Radioresistant Genes

Published on: May 23, 2025

1.4K

Area of Science:

  • Oncology
  • Trace Element Research
  • Chemotherapy Efficacy

Background:

  • Trace elements may influence hepatocellular carcinoma (HCC) development and chemotherapy effectiveness.
  • Understanding these associations is crucial for improving HCC treatment strategies.

Purpose of the Study:

  • To investigate the relationship between trace element levels and chemotherapy efficacy in HCC patients.
  • To explore how specific trace elements in tumor tissues correlate with drug sensitivity.

Main Methods:

  • Collected cancerous, adjacent, and healthy liver tissues from 55 HCC patients.
  • Analyzed trace element concentrations (Zinc, Copper, Manganese, Selenium) using atomic absorption spectrophotometry.
  • Assessed in vitro sensitivity of cancer cells to five chemotherapeutic agents via MTT assay in 32 patients.

Main Results:

  • Zinc, copper, manganese, and selenium levels showed a gradient: cancer < cancer-adjacent < cancer-free tissues.
  • Carboplatin sensitivity was negatively correlated with selenium levels; doxorubicin sensitivity was negatively correlated with manganese levels in cancer tissues.
  • Partial correlation confirmed doxorubicin sensitivity's negative correlation with manganese levels.

Conclusions:

  • Selenium and manganese content in primary HCC tissues may impact the response to carboplatin and doxorubicin.
  • These findings suggest trace elements as potential biomarkers for predicting chemotherapy response in HCC.