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Related Experiment Video

Updated: Mar 24, 2026

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
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Surface Engineering of Nanostructured Titanium Implants with Bioactive Ions.

H-S Kim, Y-J Kim, J-H Jang

    Journal of Dental Research
    |March 11, 2016
    PubMed
    Summary

    Bioactive ion modification of nanostructured titanium implants significantly boosts osteogenic activity. Strontium ions, in particular, enhance stem cell differentiation and focal adhesion development for improved bone healing.

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    Area of Science:

    • Biomaterials Science
    • Regenerative Medicine
    • Dental Implantology

    Background:

    • Titanium (Ti) implants utilize surface nanofeatures and bioactive ions to improve osseointegration.
    • The precise role of bioactive ions in enhancing osteogenic capacity on nanostructured Ti surfaces requires further elucidation.

    Purpose of the Study:

    • To systematically investigate how bioactive ions (calcium [Ca] and strontium [Sr]) influence the osteogenesis of human multipotent adipose stem cells on nanostructured Ti implants.
    • To elucidate the molecular mechanisms underlying enhanced osteogenic activity, including focal adhesion development and gene expression.

    Main Methods:

    • Surface modification of nanostructured Ti implants with Ca or Sr ions.
    • Culturing human multipotent adipose stem cells (hADSCs) on modified Ti surfaces.
    • Assessing osteogenic activity, focal adhesion development, and expression of key adhesion-related genes (vinculin, talin, RHOA).
    • Comparing the effects of Sr and Ca ions, and evaluating their influence on mesenchymal stem cell (MSC) differentiation (osteogenesis vs. adipogenesis).

    Main Results:

    • Bioactive ion release from nanostructured Ti surfaces significantly increases osteogenic activity.
    • Ion modification actively induces focal adhesion development and upregulates critical adhesion-related genes in hADSCs.
    • Strontium (Sr) ions demonstrate a dominant effect, overriding calcium (Ca) and other surface factors in promoting osteogenesis across various MSC sources.
    • Fibronectin adsorption appears to have a minimal impact on early cellular events for Sr-modified Ti implants.

    Conclusions:

    • Surface modification with bioactive ions, especially Sr, enhances the osteogenic potential of nanostructured Ti implants.
    • Ion release and induced focal adhesion development are key mechanisms driving improved osseointegration.
    • Sr ion modification offers a promising strategy for advanced dental implant surface design, balancing MSC differentiation for superior bone healing.