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Current treatment approaches and trials in central sleep apnea

Rami N Khayat1, William T Abraham2

  • 1Sleep Heart Program, The Ohio State University, Columbus, OH, United States.

International Journal of Cardiology
|March 11, 2016
PubMed

Insights

Central sleep apnea (CSA) is common in heart failure with reduced ejection fraction (HFrEF) and lacks effective treatments. This review covers current CSA therapies and trials in HFrEF patients.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Pulmonology

Background:

  • Central sleep apnea (CSA) frequently co-occurs with heart failure with reduced ejection fraction (HFrEF).
  • CSA in HFrEF patients is linked to adverse health outcomes.
  • Current therapeutic options for CSA remain limited and not universally accepted.

Purpose of the Study:

  • To review existing and emerging therapies for central sleep apnea (CSA).
  • To analyze clinical trial data on the efficacy of CSA treatments in patients with HFrEF.

Main Methods:

  • Literature review of published clinical trials.
  • Synthesis of data on therapeutic interventions for CSA.
  • Focus on studies involving patients with heart failure with reduced ejection fraction.

Main Results:

  • Analysis of various treatment modalities for CSA.
  • Evaluation of trial outcomes for CSA interventions in HFrEF.
  • Identification of gaps in current treatment strategies.

Conclusions:

  • There is a need for effective, evidence-based therapies for CSA in HFrEF.
  • Further research and clinical trials are essential to establish optimal treatment guidelines.

Keywords:
Central sleep apneaContinuous positive airway pressureHeart failurePhrenic nerve stimulationSleep apnea

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