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In Vitro Antimicrobial Susceptibility of Staphylococcus pseudintermedius Isolates of Human and Animal Origin

Romney M Humphries1, Max T Wu2, Lars F Westblade3

  • 1UCLA David Geffen School of Medicine, Los Angeles, California, USA rhumphries@mednet.ucla.edu.

Journal of Clinical Microbiology
|March 11, 2016
PubMed

Insights

Methicillin-resistant Staphylococcus intermedius group bacteria show susceptibility to doxycycline and clindamycin. All tested isolates remained susceptible to newer antibiotics like ceftaroline and vancomycin, indicating potential treatment options.

Area of Science:

  • Veterinary Microbiology
  • Antimicrobial Resistance
  • Clinical Diagnostics

Background:

  • The Staphylococcus intermedius group (SIG) comprises important veterinary pathogens.
  • Methicillin resistance is a growing concern in staphylococcal infections.
  • Understanding antimicrobial susceptibility patterns is crucial for effective treatment.

Purpose of the Study:

  • To determine the antimicrobial susceptibility profiles of Staphylococcus intermedius group isolates.
  • To assess the prevalence of methicillin resistance within this group.
  • To identify effective therapeutic options for SIG infections.

Main Methods:

  • Microbiological analysis of 115 Staphylococcus intermedius group isolates.
  • Determination of Minimum Inhibitory Concentration (MIC) values for various antimicrobial agents.
  • Detection of specific resistance genes (mupA, qacA/B).

Main Results:

  • 33% of isolates were methicillin-resistant Staphylococcus intermedius group (MRSIG).
  • Among MRSIG, susceptibility was observed for doxycycline (51.4%), clindamycin (29.7%), and trimethoprim-sulfamethoxazole (21.6%).
  • All isolates were susceptible to ceftaroline, daptomycin, linezolid, nitrofurantoin, quinupristin-dalfopristin, rifampin, tigecycline, and vancomycin.

Conclusions:

  • Methicillin-resistant Staphylococcus intermedius group (MRSIG) isolates demonstrate varied susceptibility to common antibiotics.
  • Doxycycline and clindamycin may serve as treatment options for MRSIG infections.
  • The universal susceptibility to newer agents highlights their potential in managing resistant staphylococcal infections.

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