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Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
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Brain tumors in infants.

Seyyed Mohammad Ghodsi1, Zohreh Habibi2, Sara Hanaei2

  • 1Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Science, Tehran, Iran.

Journal of Pediatric Neurosciences
|March 11, 2016
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Infant brain tumors require surgical resection, often followed by chemotherapy, for optimal outcomes. This study highlights key symptoms, diagnoses, and survival rates in young children with brain tumors.

Keywords:
Brain tumorinfantssurgical treatment

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Area of Science:

  • Pediatric Neurosurgery
  • Pediatric Oncology
  • Childhood Brain Tumors

Background:

  • Infant brain tumors exhibit distinct clinical and pathological characteristics compared to older children.
  • Early diagnosis and treatment are crucial for improving prognosis in infants.

Purpose of the Study:

  • To analyze the clinical presentation, surgical management, histopathological findings, and outcomes of primary brain tumors in infants.
  • To identify factors influencing survival and disease control in this specific population.

Main Methods:

  • Retrospective analysis of 31 infants (<12 months) treated for primary brain tumors between 2008 and 2014.
  • Data collected included clinical symptoms, tumor location, surgical procedures, histopathology, and patient outcomes.

Main Results:

  • Common symptoms included increased head circumference, bulging fontanel, and vomiting. Primitive neuroectodermal tumors were most frequent.
  • Gross total resection was achieved in 19 patients. 30-day mortality was 19.3%. Overall survival was 58%, with 41.9% disease-free survival.

Conclusions:

  • Surgical resection is the primary treatment for infant brain tumors.
  • Adjuvant chemotherapy may be necessary for complete tumor control and improved survival rates.