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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

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Published on: December 21, 2019

Primary parietal myeloid sarcoma.

Laxminadh Sivaraju¹, Dilip Mohan¹, Nandita Ghosal²

¹Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka, India.

Journal of Pediatric Neurosciences

|March 11, 2016

Summary

Intracranial myeloid sarcoma, a rare tumor without systemic disease, can mimic meningioma. This case highlights its distinct presentation and successful treatment with chemotherapy.

Keywords:

Immunohistochemistry intracranial myeloid sarcoma parietal

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Published on: September 13, 2019

Area of Science:

Neurology
Oncology
Pathology

Background:

Intracranial myeloid sarcoma is rare, especially without systemic hematological disorders.
Myeloid sarcoma can present as an extra-axial mass, mimicking other tumors like meningioma.

Observation:

A 17-year-old female presented with symptoms of increased intracranial pressure and paraparesis.
MRI revealed a large, contrast-enhancing extra-axial mass in the parasagittal region.
Subtotal tumor excision was performed, with histology confirming myeloid sarcoma.

Findings:

Peripheral blood smear and bone marrow biopsy excluded leukemia and myeloproliferative disorders.
The intracranial mass exhibited radiological and intraoperative features similar to meningioma.
Immunohistochemistry was crucial for definitive diagnosis of myeloid sarcoma.

Implications:

This case underscores the importance of considering myeloid sarcoma in the differential diagnosis of intracranial masses, even in the absence of systemic disease.
Early diagnosis and appropriate chemotherapy can lead to significant clinical improvement.
Further research into the specific characteristics and management of isolated intracranial myeloid sarcoma is warranted.