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Spontaneous brain tumor imaging of aged rat by crystal X-ray interferometer-based phase-contrast X-ray CT
Thet-Thet Lwin1, Akio Yoneyama2, Atsuko Hara3
1Allied Health Sciences, Kitasato University, Sagamihara, Japan; Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
Background:
Crystal X-ray interferometer-based phase-contrast X-ray computed tomography (C-PCCT) enables the depiction of internal structures of biological tissue without contrast agents.
Purpose:
To determine the advantage of this technique in visualizing detailed morphological structures of a rare spontaneous brain tumor in an aged rat.
Material And Methods:
An aged rat's spontaneous brain tumor was imaged by C-PCCT without contrast agent. Three-dimensional (3D) images of the tumor microvasculature were reconstructed and compared with pathological pictures.
Results:
C-PCCT depicted the tumor's various pathological features clearly, e.g. its cell density and vasculature, and blood clots caused by hemorrhaging and/or hematomas. The obtained images resembled pathological pictures with a magnification of ×20 and were used to reconstruct 3D images of the tumor vascularity up to approximately 26 µm in diameter.
Conclusion:
Since C-PCCT is able to depict various pathological conditions, it might be useful for cancer research.
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