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Prolong Exposure of NSAID in Patients With RA Will Decrease the Risk of Dementia: A Nationwide Population-Based
Kuang-Hsi Chang1, Yi-Chao Hsu, Chih-Chao Hsu
1From the Department of Public Health (K-HC), China Medical University, Taichung; Institute of Biomedical Sciences (Y-CH), Mackay Medical College, Taipei; Department of Medical Research (C-CH), Taichung Veterans General Hospital; Management Office for Health Data (C-LL), China Medical University Hospital; Graduate Institute of Clinical Medical Science (CYH, C-HK), China Medical University, Taichung; School of Chinese Medicine for Post-Baccalaureate (C-YL), I-Shou University, Kaohsiung; Division of Hepatology and Gastroenterology (L-WC), Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei; Respiratory Therapy Intensive Care Unit (H-CL), Taichung Veterans General Hospital, Taichung; Department of Nuclear Medicine (M-CL), E-Da Hospital, I-Shou University, Kaohsiung; and Department of Nuclear Medicine and PET Center (C-HK), China Medical University Hospital, Taichung, Taiwan.
This study found that rheumatoid arthritis patients using nonsteroidal anti-inflammatory drugs (NSAIDs) for over 2191 days had a significantly lower risk of dementia. Long-term NSAID use may reduce dementia risk in RA patients.
Area of Science:
- Rheumatology
- Neurology
- Pharmacology
Background:
- Rheumatoid arthritis (RA) is a chronic inflammatory disease impacting joints.
- RA is linked to increased dementia risk due to inflammation, cardiovascular issues, and depression.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are standard treatments for RA symptoms.
Purpose of the Study:
- To investigate the association between NSAID treatment and dementia risk in rheumatoid arthritis patients.
- To evaluate if NSAID duration influences dementia risk in RA patients.
Main Methods:
- A nationwide study using the Registry of Catastrophic Illnesses Patient Database (RCIPD).
- RA cohort (diagnosed 2000-2011) compared to a matched non-RA cohort.
- Cox proportional hazard models estimated relative dementia risks.
Main Results:
- No significant difference in dementia risk between RA and non-RA cohorts (aHR=0.95).
- Significantly lower dementia risk observed in RA patients with NSAID treatment duration >2191 days (aHR=0.56).
Conclusions:
- Longer duration of NSAID treatment may be associated with a reduced risk of dementia in RA patients.
- Further research is needed to confirm the link between NSAID use and dementia risk in RA.
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