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A Drug-Free Zone--Lymph Nodes as a Safe Haven for HIV
1The Ragon Institute of MGH, MIT & Harvard, 400 Technology Square, Cambridge, MA 02139, USA.
Cell Host & Microbe
|March 11, 2016
Abstract:
Understanding where and how the HIV latent reservoir persists is essential for developing rational HIV cure strategies. In a recent paper in Nature, Lorenzo-Redondo et al. (2016) demonstrate that HIV persists and actively evolves within lymph nodes due to low antiretroviral drug penetration, revealing the need to target these drug-privileged sites.