Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nonlinear Pharmacokinetics: Role of Transporters01:27

Nonlinear Pharmacokinetics: Role of Transporters

362
A drug's nonlinear kinetics can be influenced by a diverse range of transporter proteins that serve as crucial players in drug distribution. These transporters, found within cells, can enhance or reduce local drug concentrations by facilitating the influx or efflux of drugs. For instance, the expression of xenobiotic transporters can be influenced by factors such as age and gender, potentially impacting the linearity of drug response.
Polymorphisms occurring in drug transporters can alter...
362
Bioequivalence Data: Statistical Interpretation01:16

Bioequivalence Data: Statistical Interpretation

319
The statistical interpretation of bioequivalence data is a significant aspect of pharmaceutical research. Bioequivalence refers to the absence of any significant difference in the rate and extent to which the active ingredient in pharmaceutical products becomes available at the site of drug action when administered at the same molar dose under similar conditions. This helps determine if different drug products have similar absorption rates, ensuring their interchangeability.Statistical...
319
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

370
Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
370
Regression Toward the Mean01:52

Regression Toward the Mean

7.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
7.3K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

520
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
520
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters01:16

Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

110
The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
110

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antimicrobial Resistance (AMR) Consequences of the use of Doxycycline for Prevention of Bacterial Sexually Transmitted Infections (STIs): A Systematic Review.

Sexually transmitted diseases·2026
Same author

Profile and predictors of mortality among free-living elderly subjects: a community-based prospective cohort study from Kerala, India.

BMJ public health·2026
Same author

AppRaise: Software for Quantifying Evidence Uncertainty in Systematic Reviews Using a Posterior Mixture Model.

Journal of evaluation in clinical practice·2025
Same author

Clinical Practice Guidelines: Quality, Breadth, and Currency.

Annals of the American Thoracic Society·2025
Same author

Readmissions after next-day discharge following transcatheter aortic valve implantation.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·2024
Same author

Meaningful Endpoints for Idiopathic Pulmonary Fibrosis (IPF) Clinical Trials: Emphasis on 'Feels, Functions, Survives'. Report of a Collaborative Discussion in a Symposium with Direct Engagement from Representatives of Patients, Investigators, the National Institutes of Health, a Patient Advocacy Organization, and a Regulatory Agency.

American journal of respiratory and critical care medicine·2024

Related Experiment Video

Updated: Mar 24, 2026

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.6K

Transportability in Network Meta-analysis.

Conrad Kabali1, Marya Ghazipura

  • 1From the aEvidence Development and Standards Branch, Health Quality Ontario, Ontario, Canada; bDivision of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Ontario, Canada; and cDepartment of Environmental Health Sciences, New York University Langone Medical Center, New York, NY.

Epidemiology (Cambridge, Mass.)
|March 11, 2016
PubMed
Summary

Network meta-analysis enables comparing multiple treatments, even without direct head-to-head trials. This study introduces transportability to address bias from indirect treatment effect comparisons in network meta-analysis.

More Related Videos

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
09:50

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

Published on: February 12, 2015

11.7K
Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis
07:11

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Published on: November 10, 2023

3.5K

Related Experiment Videos

Last Updated: Mar 24, 2026

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

1.6K
Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
09:50

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

Published on: February 12, 2015

11.7K
Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis
07:11

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Published on: November 10, 2023

3.5K

Area of Science:

  • Biostatistics
  • Clinical Epidemiology
  • Comparative Effectiveness Research

Background:

  • Network meta-analysis (NMA) extends pairwise comparisons to include treatments not directly compared.
  • NMA is increasingly used in comparative effectiveness research for simultaneous multi-treatment effect evaluation.
  • Indirect comparisons in NMA can introduce bias due to unaddressed covariate differences across trials.

Purpose of the Study:

  • To formally address and propose a method for mitigating bias in network meta-analysis.
  • To investigate the validity of estimating indirect treatment effects in NMA.
  • To demonstrate the application of transportability for valid indirect effect estimation.

Main Methods:

  • Utilized the graphical method of transportability.
  • Assessed the conditions under which indirect treatment effects can be validly estimated in NMA.
  • Contrasted the transportability approach with traditional meta-regression for covariate adjustment.

Main Results:

  • Transportability provides a formal framework to assess the validity of indirect effects in NMA.
  • Meta-regression may yield biased estimates, especially with post-treatment covariates.
  • Demonstrated how transportability can guide the valid use of indirect evidence in NMA.

Conclusions:

  • Transportability offers a robust graphical method to ensure the validity of indirect treatment effect estimation in network meta-analysis.
  • Addressing covariate imbalance, particularly post-treatment variables, is crucial for unbiased NMA.
  • This approach enhances the reliability of comparative effectiveness research using NMA.