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[Asthma-COPD overlap syndrome].

Elif Şen1, Kıvılcım Oğuzülgen, Sevim Bavbek

  • 1Department of Chest Diseases, Faculty of Medicine, Ankara University, Ankara, Turkey. esen@ankara.edu.tr.

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Asthma-COPD Overlap Syndrome (ACOS) affects patients with features of both asthma and COPD. This condition leads to frequent exacerbations and impaired quality of life, requiring tailored treatment approaches.

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Area of Science:

  • Pulmonology
  • Respiratory Medicine
  • Clinical Medicine

Background:

  • Asthma and COPD are prevalent chronic respiratory diseases.
  • Asthma-COPD Overlap Syndrome (ACOS) presents with overlapping clinical and inflammatory features of both conditions.
  • ACOS is defined by persistent airflow limitation with reversible obstruction.

Purpose of the Study:

  • To define Asthma-COPD Overlap Syndrome (ACOS).
  • To outline diagnostic criteria for ACOS.
  • To discuss the prevalence, characteristics, and management of ACOS.

Main Methods:

  • Literature review of existing case series and guidelines.
  • Analysis of diagnostic criteria including spirometry and patient history.
  • Examination of prevalence data and demographic trends.

Main Results:

  • ACOS is characterized by persistent airflow limitation (postbronchodilator FEV1/FVC < 70%) and reversible airway obstruction.
  • Prevalence ranges from 11-55%, increasing with age and more common in females.
  • ACOS patients are typically younger than COPD patients but older than asthma patients.

Conclusions:

  • ACOS is associated with frequent severe exacerbations, hospitalizations, and reduced quality of life.
  • Current pharmacologic treatment combines optimal asthma and COPD therapies.
  • Future ACOS guidelines should focus on endotype-driven therapeutic strategies.