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Detection of Architectural Distortion in Prior Mammograms via Analysis of Oriented Patterns
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Developing Asymmetries at Mammography: A Multimodality Approach to Assessment and Management.

Allyson L Chesebro1, Nicole S Winkler1, Robin L Birdwell1

  • 1From the Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115.

Radiographics : a Review Publication of the Radiological Society of North America, Inc
|March 11, 2016
PubMed
Summary

A developing asymmetry on mammograms requires careful evaluation due to its potential link to breast cancer. Multimodality imaging, including mammography, tomosynthesis, and ultrasound, aids in diagnosis.

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Area of Science:

  • Radiology
  • Medical Imaging
  • Breast Imaging

Background:

  • Developing asymmetry is a new or more conspicuous finding on mammography.
  • It presents diagnostic challenges due to similarity with fibroglandular tissue.
  • It is an uncommon but suspicious sign of breast cancer.

Purpose of the Study:

  • To define developing asymmetry.
  • To describe multimodality diagnostic tools for its evaluation.
  • To review its benign and malignant causes.

Main Methods:

  • Diagnostic mammography with additional views (spot compression, lateral, rolled).
  • Digital breast tomosynthesis for improved sensitivity, specificity, and localization.
  • Targeted ultrasonography (US) for identifying causes or biopsy targets.
  • Diagnostic breast magnetic resonance imaging (MRI) for problem-solving or biopsy planning when US is inconclusive or stereotactic biopsy is not feasible.

Main Results:

  • Diagnostic mammography is foundational for evaluating developing asymmetry.
  • Digital breast tomosynthesis enhances lesion characterization and localization.
  • Targeted US helps differentiate benign causes or target biopsies, though its absence doesn't rule out malignancy.
  • MRI serves a role in specific challenging cases.

Conclusions:

  • Developing asymmetry is a concerning finding requiring thorough investigation.
  • A combination of imaging modalities is crucial for accurate diagnosis.
  • Prompt and appropriate diagnostic workup is essential for patient management.