Related Experiment Video
Updated: Mar 24, 2026
Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Platelet-Rich Plasma in Grafted Maxillae: Growth Factor Quantification and Dynamic Histomorphometric Evaluation
Mohamed Badr1, Richard Oliver, Philip Pemberton
1*Lecturer of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Minia University, Minia, Egypt. †Honorary Senior Lecturer of Oral and Maxillofacial Surgery, Cardiff University, Cardiff, UK. ‡Senior Clinical Scientist, Department of Biochemistry, Central Manchester University Hospitals, Manchester, UK. §Head of School of Dentistry and Professor of Oral and Maxillofacial Surgery, The University of Manchester, Manchester, UK.
Platelet-rich plasma (PRP) enhances bone healing by increasing growth factors and bone formation rates in iliac crest grafts. Further research is needed to confirm clinical significance.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Orthopedic Surgery
Background:
- Iliac crest grafts are crucial for bone reconstruction.
- Optimizing graft healing is essential for successful implant integration.
Purpose of the Study:
- To validate the platelet-rich plasma (PRP) system.
- To assess PRP's effect on iliac crest graft healing before dental implant placement.
Main Methods:
- Randomized controlled trial with test (PRP) and control groups.
- PRP mixed with iliac crest grafts in the test group.
- Histomorphometrical analysis and growth factor quantification.
Main Results:
- PRP group showed higher platelet counts, PDGF-BB, and TGF-β1.
- Increased woven bone volume and seam separation in the PRP group.
- Enhanced remodeling activity observed in PRP-treated bone.
Conclusions:
- PRP significantly boosts platelet and growth factor levels.
- PRP shows a potential enhancing effect on bone formation rate.
- Clinical significance of PRP in graft healing requires further investigation.
More Related Videos
08:34Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
Published on: February 24, 2021
09:34Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
Published on: September 7, 2017