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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

2.7K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Introduction to Hemostasis01:05

Introduction to Hemostasis

16.2K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
16.2K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

15.2K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
15.2K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

10.6K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
10.6K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.3K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.3K
Coagulation01:09

Coagulation

11.9K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
11.9K

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Articles linked to this work by shared authors, journal, and citation graph.

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[FUNCTIONAL AND CLINICAL DISORDERS OF THE LUNG IN PATIENTS WITH CIRRHOSIS AND THEIR DYNAMICS IN OPERATIONS TUNNELING LIVER].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology·2018
Same author

[CLINICAL CHARACTERISTICS OF PATIENTS WITH ARTERIAL HYPERTENSION ASSOCIATED WITH PEPTIC DUODENAL ULCER AFTER ACUTE GASTROINTESTINAL BLEEDING].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology·2018
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[THE EFFICIENCY OF SCHOOL OF COMBINED PATHOLOGY IN THE REHABILITATION OF PATIENTS WITH PEPTIC DUODENAL ULCER ASSOCIATED WITH ARTERIAL HYPERTENSON AFTER ACUTE GASTROINTESTINAL BLEEDING].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology·2018
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[THE INFLUENCE OF TUMOR NECROSIS FACTOR ALPHA AND POLYMORPHISM OF ITS GENE (RS1800629) ON THE SEVERITY AND PROGRESSION OF CHRONIC HEPATITIS AND ULCERATIVE COLITIS].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology·2016
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[Cardiovascular disorders in case of acute gastrointestinal bleeding in patients with arterial hypertension].

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[Metabolic disorder and polymorphism of the genes encoding for beta-2-adrenergic receptor and apolipoproteins B in chronic hepatitis C and non-alcoholic fatty liver diseases].

Klinicheskaia meditsina·2015

Related Experiment Video

Updated: Mar 24, 2026

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
08:13

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice

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[POSTPARTUM ACQUIRED HEMOPHILIA].

P N Barlamov, V V Shchekotov, A A Shutylev

    Klinicheskaia Meditsina
    |March 12, 2016
    PubMed
    Summary

    This review covers acquired hemophilia, a rare bleeding disorder. It details causes, symptoms, diagnosis, and treatment, including a successful postpartum case.

    Area of Science:

    • Hematology
    • Internal Medicine

    Background:

    • Acquired hemophilia is a rare autoimmune disorder characterized by autoantibodies against coagulation factor VIII.
    • It presents a diagnostic and therapeutic challenge due to its rarity and potential for severe bleeding.

    Observation:

    • This review synthesizes current knowledge on the etiology, pathogenesis, clinical manifestations, and diagnostic approaches for acquired hemophilia.
    • A specific case report highlights the successful management of postpartum acquired hemophilia.

    Findings:

    • The review outlines the diagnostic algorithm, emphasizing the importance of early recognition and appropriate laboratory testing.
    • Treatment strategies discussed include immunosuppression and factor VIII replacement therapy.

    Implications:

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    • Understanding the complexities of acquired hemophilia is crucial for timely diagnosis and effective patient management.
    • The successful postpartum case underscores the feasibility of achieving hemostasis in challenging clinical scenarios.