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Updated: Mar 24, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
Functional brain imaging, sleep, and sleep deprivation: contributions to the "overarousal" hypothesis of depression
J C Gillin1, A P Ho1, M S Buchsbaum2
1University of California, San Diego and San Diego VA Medical Center.
Abstract:
In 1975 van den Burg and van den Hoofdakker hypothesized that depressed patients might be 'overaroused.' This suggestion is consistent not only with their seminal observations on the antidepressant effects of total sleep deprivation in depression, but with the short, fragmented, and shallow sleep of depressed patients, lowered arousal thresholds, hyperactivity of the hypothalamus-pituitary adrenal (HPA) axis, and elevated core body temperature commonly found in some patients during the sleep period.
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