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Hibernation-like neuroprotection in stroke by attenuating brain metabolic dysfunction
Brian Forreider1, David Pozivilko2, Qingwen Kawaji1
1Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI, USA.
Progress in Neurobiology
|March 12, 2016
Summary
Mammalian hibernation offers neuroprotection during low blood flow. Inducing a hibernation-like state may protect human brain tissue from ischemic stroke damage.
Area of Science:
- Neuroscience
- Physiology
- Biochemistry
Background:
- Hibernation in mammals involves significant metabolic and physiological changes.
- Mammals maintain central nervous system integrity despite reduced cerebral blood flow during hibernation.
- This neuroprotective ability holds potential for treating human ischemic stroke.
Purpose of the Study:
- To review and evaluate true hibernation.
- To assess the neuroprotective characteristics of hibernation-like states.
- To examine methods for inducing artificial hibernation and their mechanisms against ischemic damage.
Main Methods:
- Review of scientific literature on mammalian hibernation.
- Analysis of preclinical and clinical studies on therapeutic hypothermia, phenothiazine drugs, and ethanol for inducing hibernation-like states.
- Evaluation of the mechanisms underlying ischemia-induced tissue damage and protective effects of artificial hibernation.
Main Results:
- True hibernation involves profound metabolic suppression and neuroprotection.
- Hibernation-like states demonstrate potential neuroprotective effects against ischemia.
- Therapeutic hypothermia, phenothiazines, and ethanol are methods to induce such states, mitigating ischemia-mediated damage.
Conclusions:
- Artificial hibernation strategies, mimicking natural hibernation, show promise for neuroprotection in ischemic stroke.
- Understanding hibernation mechanisms can guide the development of novel stroke therapies.
- Further research into artificial hibernation is warranted for clinical application in stroke patients.
