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Updated: Mar 24, 2026

Strategies for Assessing Autistic-Like Behaviors in Mice
Published on: September 20, 2024
Autism and autistic-like disorders: the hypothalamic-pituita-ry-adrenal system as a model for research
L M Jansen1, C C Wied1, H V Engeland1
1Onderzoeksschool Rudolf Magnus Instituut,Afdeling Kinder- en Jeugdpsychiatrie,Universiteit van Utrecht,Academisch Ziekenhuis.
Abstract:
In this article an overview is given of the differential diagnosis of autism and autistic-like disorders. The diagnosis of the so-called 'Multiple Complex Developmental Disorders' (MCDD) as a distinct entity is discussed in relation to autism and schizophrenia. Biological research and the relevance of results until recently are discussed. Finally, the importance of the hypothalamic-pituitary-adrenal system (HPA system) as a model for research is proposed. Research on the flexibility of this system may contribute in understanding the ways of stress processing in disorders like autism, MCDD and schizophrenia.
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