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Association between three exonuclease 1 polymorphisms and cancer risks: a meta-analysis

Zi-Yu Chen1, Si-Rong Zheng2, Jie-Hui Zhong1

  • 1Department of Clinical Medicine, The First Clinical Medical College, Southern Medical University, Guangzhou, People's Republic of China; Institute of Genetic Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China.

Oncotargets and Therapy
|March 12, 2016
PubMed
Summary

Exonuclease 1 (Exo1) Pro757Leu polymorphism may reduce cancer risk, while Glu589Lys may increase it, especially in smokers. The Glu670Gly polymorphism shows no significant cancer risk association. Further research is needed for definitive conclusions.

Keywords:
cancer risksexonuclease 1meta-analysispolymorphism

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