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The use of long-term bone marrow cultures (LTBMC) to detect hematotoxic side effects of purging methods
E Schulze1, W Helbig, U Hofmann
1Department of Internal Medicine, Karl-Marx-University, Leipzig, German Democratic Republic.
Haematology and Blood Transfusion
|January 1, 1989
Abstract:
With a view to the establishment of purging methods it is necessary to investigate complete-remission bone marrow as the real target of purging, rather than bone marrow from healthy donors. The results of LTBMC are superior to those of GM-CFC where the hematopoietic recovery of bone marrow is concerned. One-stage LTBMC after bone marrow manipulations may reflect mixed hematopoietic/stromal effects. The use of two-stage LTBMC allows the evaluation of the stem cell recovery without the possible influence of a damaged microenvironment.