Related Experiment Video
Updated: Mar 24, 2026
Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
Published on: August 15, 2025
Risk Factors for Life-Threatening Complications of Maxillofacial Space Infection
Xiaodong Han1, Jingang An, Yi Zhang
1Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology. Beijing, China.
Abstract:
The purpose of this study was to review the clinical features of maxillofacial space infection (MSI), and to identify the potential risk factors predisposing to life-threatening complications. A retrospective review of the medical charts of patients with MSI treated at Peking University School and Hospital of Stomatology from August 2008 to September 2013 was conducted. A total of 127 patients [75 men (59.1%) and 52 women (40.9%); mean age, 45.39 ± 21.18 years, with a range of 1-85 years] formed the study cohort. The most common cause of MSI was odontogenic infection (57.5%). The most common space involved was the submandibular space. All patients were treated by antibiotics as well as surgical incision and drainage. Sixteen patients developed life-threatening complications, and the dominant complication was respiratory obstruction. Multivariate logistic regression analysis revealed the percentage of neutrophils (NEUT%) upon hospital admission ≥ 85.0% to be associated with life-threatening complications (P < 0.05). Even though adequate antibiotic therapy and incision and drainage of abscess were given, MSI patients with NEUT% upon hospital admission ≥ 85.0% carry a higher risk of life-threatening complications. In these patients, an aggressive treatment strategy is mandatory.
Insights
Maxillofacial space infections (MSI) often stem from dental issues. High neutrophil percentages (NEUT%) at admission indicate a greater risk of severe complications, necessitating aggressive treatment.
Area of Science:
- Oral and Maxillofacial Surgery
- Infectious Diseases
Background:
- Maxillofacial space infections (MSI) are serious conditions requiring prompt management.
- Odontogenic infections are a primary cause of MSI.
- Identifying risk factors for life-threatening complications is crucial for patient outcomes.
Purpose of the Study:
- To review the clinical characteristics of maxillofacial space infections (MSI).
- To identify risk factors associated with life-threatening complications in MSI patients.
Main Methods:
- Retrospective review of 127 MSI patients treated between August 2008 and September 2013.
- Analysis of clinical data, including demographics, infection source, involved spaces, and treatment outcomes.
- Multivariate logistic regression to identify predictors of severe complications.
Main Results:
- Odontogenic infection was the most frequent cause (57.5%), with the submandibular space most commonly affected.
- Sixteen patients (12.6%) experienced life-threatening complications, predominantly respiratory obstruction.
- A neutrophil percentage (NEUT%) of ≥ 85.0% upon hospital admission was significantly associated with increased risk of severe complications (P < 0.05).
Conclusions:
- Maxillofacial space infections require prompt antibiotic therapy and surgical drainage.
- Elevated neutrophil counts at admission are a key indicator for predicting severe MSI complications.
- Patients with NEUT% ≥ 85.0% require aggressive management strategies to mitigate life-threatening risks.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:26Tonsillitis II: Management
01:30Tonsillitis I: Introduction
Etiology
Three primary contributing factors have been identified.
01:26Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
01:22Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
01:30Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...