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Related Experiment Videos

[Fluorescence perfusion scintigraphy. A new method for quantifying ocular circulatory disorders].

J E Nasemann, R Kantlehner, C M Kirsch

    Fortschritte Der Ophthalmologie : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft
    |January 1, 1989
    PubMed
    Summary

    A new method, fluorescence perfusion scintigraphy (FLUPS), measures carotid-retina circulation time. This technique revealed significantly delayed circulation in patients with retinal vein occlusion, highlighting its value in monitoring ocular blood flow defects.

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    Area of Science:

    • Ophthalmology
    • Medical Imaging
    • Cardiovascular Science

    Background:

    • Ocular circulation time is crucial for diagnosing retinal vascular diseases.
    • Existing methods for measuring ocular circulation time lack high resolution or are invasive.
    • A need exists for a precise, non-invasive method to assess carotid-retina transit time.

    Purpose of the Study:

    • To introduce and validate a novel clinical method, fluorescence perfusion scintigraphy (FLUPS).
    • To measure the circulation time between the carotid artery and the retina with high resolution.
    • To assess interocular differences in circulation time in patients with retinal vein occlusion.

    Main Methods:

    • FLUPS involves injecting a bolus of Na-fluorescein and 99mTc-DTPA into the antecubital vein.

    Related Experiment Videos

  • Carotid artery transit is detected using a transdermal gamma emission detector.
  • Retinal arrival is simultaneously recorded via scanning laser ophthalmoscopy for high-resolution angiograms.
  • A picture analysis system quantifies fluorescence intensity changes over the optic disc.

    • Main Results:

    • Normal carotid-retina circulation time ranged from 0.7 to 2.3 seconds.
    • Patients with central retinal vein occlusion exhibited significantly delayed carotid-retina circulation times (3-150% delay, p < 0.05).
    • FLUPS demonstrated interocular differences in circulation time in unilateral retinal vein occlusion.

    Conclusions:

    • FLUPS provides high-resolution measurement of carotid-retina circulation time.
    • The method is valuable for detecting and monitoring ocular circulation defects, particularly in retinal vascular diseases.
    • FLUPS shows potential for clinical application in ophthalmology and vascular diagnostics.