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iChip

iChip

The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...

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Related Experiment Video

Updated: May 1, 2026

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Reverse Engineering Human Pathophysiology with Organs-on-Chips.

Donald E Ingber¹

¹Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA; Vascular Biology Program, Departments of Pathology & Surgery, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02138, USA.

|March 12, 2016

Summary

This summary is machine-generated.

Human organs-on-chips provide a novel experimental system for studying intercellular communications and tissue interactions. This technology offers a more relevant organ context for understanding human pathophysiology beyond traditional cell cultures.

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Last Updated: May 1, 2026

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Area of Science:

Biomedical Engineering
Cell Biology
Pathophysiology

Background:

Cultured cell studies offer insights into biological control mechanisms.
Understanding human pathophysiology necessitates experimental systems with greater relevance.
Intercellular communications and tissue-tissue interactions are crucial for organ function.

Purpose of the Study:

To introduce human organs-on-chips as a powerful new experimental approach.
To address the limitations of current systems in studying complex organ interactions.
To facilitate a deeper understanding of human pathophysiology.

Main Methods:

Development of human organ-on-a-chip models.
Analysis of intercellular communications within the organ context.
Investigation of tissue-tissue interactions using microfluidic devices.

Main Results:

Human organs-on-chips enable analysis in a relevant organ context.
This technology facilitates the study of intercellular and tissue-tissue interactions.
Provides a more physiologically relevant model compared to traditional cell cultures.

Conclusions:

Human organs-on-chips represent a significant advancement in experimental biology.
This approach holds promise for unraveling complex mechanisms of human pathophysiology.
Offers a pathway to more accurate disease modeling and drug development.