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Systemic Amyloidosis and Extraocular Muscle Deposition.

Veeral S Shah1, Kara M Cavuoto, Hilda Capo

  • 1Department of Ophthalmology (VS), Texas Children's Hospital, Baylor College of Medicine, Houston, Texas; Department of Ophthalmology (KMC, HC, SFG, SRD, NJS), Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
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Summary
This summary is machine-generated.

Amyloid deposition in eye muscles can signal systemic amyloidosis. Early ophthalmologist recognition of this rare condition is crucial for timely diagnosis and preventing severe organ damage.

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Area of Science:

  • Ophthalmology
  • Neurology
  • Pathology

Background:

  • Systemic amyloidosis is a rare condition characterized by amyloid protein buildup in organs.
  • Extraocular muscle involvement is an uncommon presentation of systemic amyloidosis.

Observation:

  • A 67-year-old woman presented with acquired strabismus (exotropia and hypertropia).
  • Magnetic resonance imaging revealed unilateral, diffuse extraocular muscle enlargement.
  • Biopsy confirmed amyloid deposition in the affected muscle.

Findings:

  • The patient was diagnosed with systemic amyloidosis, indicated by monoclonal gammopathy.
  • Isolated amyloid deposition in an extraocular muscle was the initial presenting sign.

Implications:

  • Ophthalmologists should consider amyloidosis in the differential diagnosis of atypical acquired strabismus.
  • Early detection by ophthalmologists is vital for managing systemic amyloidosis and preventing life-threatening end-organ damage.