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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

345
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
345
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

314
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
314
Vaccinations01:51

Vaccinations

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Overview
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

330
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
330
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

311
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
311
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

319
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
319

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Updated: Mar 24, 2026

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers
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[Immunization schedule in the elderly].

Gaëtan Gavazzi1, Gilles Berrut2, Claude Jeandel3

  • 1Université Grenoble-Alpes, CNRS GREPI AGIM FRE 3405, et Clinique universitaire de médecine gériatrique, CHU de Grenoble, France.

Geriatrie Et Psychologie Neuropsychiatrie Du Vieillissement
|March 12, 2016
PubMed
Summary
This summary is machine-generated.

Vaccination is crucial for older adults to prevent severe infections. France

Keywords:
elderlyimmunization

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Area of Science:

  • Gerontology
  • Infectious Diseases
  • Public Health

Background:

  • Elderly populations are at higher risk for severe infectious diseases.
  • Vaccination is a key preventive strategy for this demographic.
  • France introduced specific vaccination recommendations for individuals over 65 in 2014.

Purpose of the Study:

  • To outline the 2014 French vaccination schedule for individuals aged 65 and older.
  • To highlight key vaccine recommendations for the elderly population.
  • To emphasize the importance of enhancing vaccination uptake in the elderly.

Main Methods:

  • Review of the 2014 French immunization schedule.
  • Analysis of vaccination recommendations for individuals over 65.
  • Inclusion of vaccines such as Tetanus-Diphtheria-Poliomyelitis (TDaP), pertussis, influenza, pneumococcal, and zoster.

Main Results:

  • Tetanus-Diphtheria-Poliomyelitis (TDaP) and pertussis vaccination recommended at 65 and every 10 years.
  • Annual influenza vaccination recommended for population benefit.
  • Pneumococcal vaccine recommended once after age 65 for high-risk groups.
  • Zoster vaccine recommended for ages 65-74, with extensions for 75-79 year olds.

Conclusions:

  • Vaccination schedules for the elderly are evolving.
  • Targeted vaccination strategies are essential for preventing infectious diseases in older adults.
  • Increased vaccination uptake and awareness are necessary for the elderly population.