Related Experiment Video
Updated: Mar 24, 2026
11:34
A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
Published on: April 11, 2025
936
Natural product derived immune-regulatory agents
1University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, NE 68198-6495, United States.
International Immunopharmacology
|March 13, 2016
Summary
Immunotherapy, a strategy for various diseases, has achieved clinical success and regulatory approval. Advances in immunotherapy have led to sophisticated, reproducible compounds with diverse mechanisms of action.
Area of Science:
- Immunology
- Pharmacology
- Oncology
Background:
- Immunotherapy has evolved significantly over the past 20 years.
- Initial approaches used crude microbial mixtures, progressing to refined compounds.
Purpose of the Study:
- To review approved and developing immunoregulatory drugs.
- To highlight agents derived from or associated with natural products.
Main Methods:
- Literature review of approved and clinical-stage immunotherapies.
- Emphasis on drugs with natural product origins or associations.
Main Results:
- The clinical goal of immunotherapy for neoplastic, infectious, autoimmune, and inflammatory diseases has been met.
- Many immunotherapies have received regulatory approval.
- Sophisticated compounds with multiple mechanisms of action are now available.
Conclusions:
- Current understanding of immunoregulatory agents aids future immunotherapy discovery.
- Natural product-derived immunotherapies represent a significant area of development.
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