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A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
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Exertional heat stroke and acute liver failure: a late dysfunction
Ana Sofia Carvalho1, Simão C Rodeia2, Joana Silvestre1
1Polyvalent Intensive Care Unit, Hospital São Francisco Xavier-Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.
BMJ Case Reports
|March 13, 2016
Summary
Exertional heat stroke (EHS) can lead to acute liver failure (ALF). Prompt cooling is vital for EHS patients, and liver function monitoring is crucial for managing this rare but serious condition.
Area of Science:
- Sports Medicine
- Environmental Physiology
- Toxicology
Background:
- Heat stroke (HS) is a critical condition characterized by elevated core body temperature and central nervous system dysfunction.
- Exertional heat stroke (EHS) with acute liver failure (ALF) is a rare but severe clinical presentation.
Observation:
- A 25-year-old male runner developed hyperthermia and neurological impairment during an outdoor marathon.
- The patient's condition required aggressive cooling, followed by the development of ALF and ICU transfer.
Findings:
- Cognitive enhancer use may have contributed to heat intolerance and the EHS event.
- The patient successfully recovered with conservative treatment, highlighting the importance of prompt intervention.
Implications:
- Aggressive total body cooling is essential for preventing EHS progression.
- Monitoring liver function is critical as it can manifest as a delayed organ dysfunction in EHS cases.
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