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A Flow Cytometry-Based Cytotoxicity Assay for the Assessment of Human NK Cell Activity
Published on: August 9, 2017
Natural killer cells, ageing and cancer
Elissaveta Naumova1, Graham Pawelec2, Anastasiya Mihaylova3
1Department of Clinical Immunology and Stem Cell Bank, University Hospital "Alexandrovska", Medical University, 1, Georgi Sofiiski str., 1431, Sofia, Bulgaria. naumovaej@gmail.com.
Abstract:
Natural killer (NK) cells are key components of innate immunity and substantially contribute to anti-tumor immune responses. The role of NK cells in immune surveillance is linked to many aspects of NK cell biology, but the age of the animal being studied or the human under treatment is rarely taken into account. The solicited reviews constituting a collection of papers presented here as a "Symposium-in-Writing" on the topic of NK cells, ageing and cancer were inspired by the increasing knowledge of NK cell biology and genetics, and emerging data on their impact in the clinic (disease associations and therapies), together with the realization that older individuals also differ from younger ones regarding innate as well as adaptive immunity.
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