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Tissue-engineered artificial oesophagus patch using three-dimensionally printed polycaprolactone with mesenchymal

Seong Yong Park1, Jae Won Choi2, Ju-Kyeong Park3

  • 1Department of Thoracic and Cardiovascular Surgery, Ajou University, Suwon, Republic of Korea.

Interactive Cardiovascular and Thoracic Surgery
|March 13, 2016
PubMed
Summary

Three-dimensional printed scaffolds coated with mesenchymal stem cells (MSCs) and fibrin successfully regenerated esophageal tissue in rabbits. This 3D printing approach shows promise for artificial esophagus development.

Keywords:
3D-printingFibrinMesenchymal stem cellOesophageal regenerationTissue engineering

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Engineering
  • Tissue Engineering

Background:

  • Growing interest in 3D printing (3DP) for tissue engineering applications.
  • Need for effective strategies to repair esophageal defects.

Purpose of the Study:

  • To evaluate the efficacy of a 3D-printed scaffold coated with mesenchymal stem cells (MSCs) in fibrin for repairing partial esophageal defects.

Main Methods:

  • Cultured rabbit bone marrow MSCs and seeded them in fibrin onto 3D-printed polycaprolactone (PCL) scaffolds.
  • Implanted 3DP/MSC scaffolds into artificial esophageal defects in three rabbits and 3DP-only scaffolds in three control rabbits.
  • Evaluated outcomes radiologically and histologically after three weeks.

Main Results:

  • No infections, stenosis, or granulation observed in any rabbits.
  • 3DP/MSC group showed complete regeneration of mucosal epithelium and smooth muscle cells.
  • 3DP-only group lacked significant mucosal epithelium and smooth muscle cell regeneration.

Conclusions:

  • 3D-printed scaffolds coated with MSCs and fibrin successfully restored esophageal shape and histology.
  • The regenerated tissue showed no signs of graft rejection.
  • This approach is a promising strategy for developing artificial esophagi.