Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combinatorial Gene Control02:33

Combinatorial Gene Control

9.9K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.9K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

26.9K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
26.9K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

4.2K
4.2K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

1.5K
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.5K
Notch Signaling Pathway03:14

Notch Signaling Pathway

6.8K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.8K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.9K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A model system test of trophic transmission of RNA interference effects using the milkweed bug Oncopeltus fasciatus (Hemiptera).

Scientific reports·2026
Same author

Segmentation gene expression and function in <i>Vanessa cardui,</i> an emerging model for Lepidoptera.

bioRxiv : the preprint server for biology·2026
Same author

The Relevance and Resilience of Evo-Devo in 2025: The Biennial Meeting of the Pan American Society for Evolutionary Developmental Biology.

Journal of experimental zoology. Part B, Molecular and developmental evolution·2026
Same author

Compensatory action of different types of cis-regulatory elements buffers the striped expression of Drosophila pair-rule genes.

Development (Cambridge, England)·2025
Same author

Arthropod Pax Gene Evolution: A Role for Vanessa Cardui Twin of Eyeless in Eye Development.

Molecular biology and evolution·2025
Same author

Recent approaches lead to a deeper understanding of diverse segmentation mechanisms in insects, with a focus on the pair-rule genes.

Current opinion in insect science·2024

Related Experiment Video

Updated: Mar 24, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

9.3K

Evo-Devo: Discovery of Diverse Mechanisms Regulating Development.

Alys M Cheatle Jarvela1, Leslie Pick1

  • 1Entomology Department, University of Maryland, College Park, Maryland, USA.

Current Topics in Developmental Biology
|March 13, 2016
PubMed
Summary

Evolutionary developmental biology (evo-devo) research has focused on conserved genes in model organisms. Expanding studies to diverse animals and lineage-specific genes is crucial for a complete understanding of development and evolution.

Keywords:
BiodiversityEvo-devoHox genesLineage-specific genes

More Related Videos

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

8.5K
Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
07:18

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Published on: October 27, 2023

3.5K

Related Experiment Videos

Last Updated: Mar 24, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

9.3K
The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
07:34

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

8.5K
Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
07:18

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Published on: October 27, 2023

3.5K

Area of Science:

  • Evolutionary developmental biology (evo-devo)
  • Genetics
  • Zoology

Background:

  • Evo-devo investigates evolutionary changes in developmental mechanisms.
  • Current research heavily relies on conserved genes from a limited set of model organisms.
  • This approach overlooks the vast diversity of metazoans.

Purpose of the Study:

  • To review the history and findings of the current evo-devo research paradigm.
  • To advocate for broadening research scope in evo-devo.
  • To highlight the necessity of studying diverse animal taxa and lineage-specific genes.

Main Methods:

  • Literature review of evo-devo research.
  • Analysis of the impact of model organism-centric studies.
  • Argumentation for a more inclusive research strategy.

Main Results:

  • The predominant research paradigm in evo-devo has yielded significant insights but is limited by its narrow focus.
  • Model organisms do not represent the full spectrum of metazoan diversity.
  • Understanding evolutionary developmental processes requires broader comparative studies.

Conclusions:

  • The current evo-devo research model, while informative, is insufficient for a comprehensive understanding of development and evolution.
  • Future evo-devo research must incorporate a wider array of animal species, including non-model organisms.
  • Investigating lineage-specific genes is essential for a complete picture of evolutionary developmental biology.