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Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos
Published on: June 6, 2016
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The Acquisition of Cell Fate in Mouse Development: How Do Cells First Become Heterogeneous?
Sarah J L Graham1, Magdalena Zernicka-Goetz1
1Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.
Current Topics in Developmental Biology
|March 13, 2016
Abstract:
Specification of cell fate in the early mouse embryo involves the generation of heterogeneities between cells in polarity, position, gene expression, and protein activity. Identifying when and how these differences first become established represents an important challenge for understanding the roles of stochastic and cell history-dependent mechanisms in mammalian development.

