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Dopaminergic mechanisms in self-inflicting biting behavior
Psychopharmacology Bulletin
|January 1, 1989
Summary
Dopamine (DA) agonists trigger self-biting behavior in animal models, but the specific DA receptor subtypes involved differ between monkey and rat models. This suggests complex dopaminergic mechanisms underlying this behavior.
Area of Science:
- Neuroscience
- Pharmacology
- Behavioral Science
Background:
- Self-inflicting biting behavior (SBB) is observed in certain neurological conditions.
- Dopaminergic (DA) systems are implicated in motor control and repetitive behaviors.
Purpose of the Study:
- To investigate the role of specific dopamine receptor subtypes in SBB using distinct animal models.
- To compare the pharmacological profiles of DA-induced SBB in monkeys and rats.
Main Methods:
- Monkeys with ventromedial tegmental (VMT) lesions received DA agonists and antagonists.
- Rats with 6-hydroxydopamine (6-OHDA) lesions underwent intrastriatal microinjections of DA agonists and antagonists.
- Behavioral responses, including SBB and spasticity, were monitored.
Main Results:
- In monkeys, mixed D1/D2 DA agonists induced SBB, blocked by D1 and D1/D2 antagonists.
- Combined D1 and D2 agonists elicited SBB in monkeys at lower doses.
- In rats, intrastriatal apomorphine induced SBB, requiring combined D1 and D2 antagonism for complete prevention.
- Dopamine agonist-induced SBB pharmacological profiles differed between the two species.
Conclusions:
- The study highlights species-specific differences in dopaminergic mechanisms underlying SBB.
- Findings suggest distinct roles for D1 and D2 receptors in SBB depending on the brain region and model.
- This research provides insights into potential therapeutic targets for SBB in conditions like Lesch-Nyhan syndrome.