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Semi-quantitative prediction of a multiple API solid dosage form with a combination of vibrational spectroscopy

A Hertrampf1, R M Sousa2, J C Menezes3

  • 1Quality Operations, Laboratory for Liquid Products, Merck Serono, Darmstadt, Germany; Institute for Biotechnology and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Portugal.

Journal of Pharmaceutical and Biomedical Analysis
|March 13, 2016
PubMed
Summary

Near-infrared (NIR) and Raman spectroscopy effectively identify and quantify pharmaceutical dosages. Combining these techniques offers enhanced accuracy for quality control, improving drug safety and efficacy.

Keywords:
Multiblock partial least squares regressionMultivariate data analysisPrincipal component analysisRaman spectroscopySequential-orthogonalised partial least squares regressionnear infrared spectroscopy

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