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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Cells Coordinate Growth and Proliferation02:36

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Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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The Notch-Mediated Proliferation Circuitry.

Diana M Ho1, Spyros Artavanis-Tsakonas2

  • 1Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.

Current Topics in Developmental Biology
|March 13, 2016
PubMed
Summary
This summary is machine-generated.

The Notch signaling pathway regulates cell proliferation through complex interactions. Understanding its genetic circuitry is key to controlling cell growth in development and cancer.

Keywords:
CancerHyperplasiaJNK signalsNotchProliferationSrc signals

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Cancer Biology

Background:

  • The Notch signaling pathway is crucial for cell fate decisions and highly conserved across species.
  • Notch signaling influences cellular proliferation, exhibiting both pro- and anti-proliferative effects.
  • Its proliferative effects can be cell-autonomous or non-cell-autonomous, varying with cellular context.

Purpose of the Study:

  • To explore the role of Notch signaling in regulating cellular proliferation.
  • To investigate the genetic factors and signaling pathways that modulate Notch-induced proliferation.
  • To understand the implications of Notch signaling in development and cancer.

Main Methods:

  • Review and analysis of existing literature on Notch signaling and proliferation.
  • Identification of key genes and pathways interacting with Notch.
  • Examination of Notch's role in cell-autonomous and non-cell-autonomous proliferation.

Main Results:

  • Notch signaling controls diverse cell fate decisions, including proliferation.
  • Interacting genes and signaling pathways, such as JNK, significantly regulate Notch's proliferative effects.
  • Notch can induce proliferation in both direct and indirect cellular manners.

Conclusions:

  • Dissecting the genetic circuitry of Notch is essential for understanding its proliferative role.
  • This knowledge is critical for both developmental processes and cancer biology.
  • Further research into Notch-gene interactions will elucidate proliferative control mechanisms.